Cyclophosphamide hyponatremia
WebNov 10, 2024 · Mesna (sodium 2-mercaptoethane sulfonate) is a detoxifying medicine used to prevent hemorrhagic cystitis in patients receiving chemotherapy with either high-dose … WebCyclophosphamide (Cytoxan; Cy) is an alkylating agent with cytotoxic and immunosuppressive activities. The parent compound is inactive in vitro and exerts its biologic activity through metabolites, mainly phosphoramide mustard generated by hepatic microsomal enzymes.
Cyclophosphamide hyponatremia
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WebNov 5, 2024 · Urine pH was monitored, and 125 mg of acetazolamide was given if urine pH <7. Mild hyponatremia was defined as plasma Na concentration raging from 125mEq/L to 135mEq/L. Severe hyponatremia was... WebDec 10, 2024 · Hyponatremia, defined as a serum sodium concentration <135 mmol/L, is caused by an excess of water relative to sodium in the extracellular fluid. Although sodium depletion may precede water retention, primary water excess can occur irrespective of sodium balance ( Figure 1 ).
WebCyclophosphamide, an agent used to treat various malignant and autoimmune disorders, can cause severe hyponatremia with seizures in rare cases. The exact … WebCyclophosphamide can cause myelosuppression (leukopenia, neutropenia, thrombocytopenia and anemia), bone marrow failure, and severe immunosuppression …
WebCyclophosphamide is an alkylating agent used in antineoplastic and immunosuppressive therapies. Symptomatic hyponatraemia is a rare but life-threatening complication in … WebSep 16, 2024 · Cyclophosphamide is a pro-drug that is activated by cytochrome P450s [see Clinical Pharmacology (12.3)]. An increase of the concentration of cytotoxic metabolites may occur with: Protease ... 8 USE IN SPECIFIC POPULATIONS
Webagents (e.g. Cyclophosphamide) Anti-depressants Tricyclic antidepressants, SSRIs, MAOI Anti-epileptic medications Carbamazepine, Sodium Valproate Anti-hypertensives ACEi, ARB, Amlodipine Anti-pyschotic medications Phenothiazines, Butyrophenones Diuretics Thiazides, Indapamide, Amiloride, loop diuretics Proton pump inhibitors Omeprazole
WebMar 1, 2024 · Cyclophosphamide can cause myelosuppression (leukopenia, neutropenia, thrombocytopenia and anemia), bone marrow failure, and severe immunosuppression which may lead to serious and … free bingo games for kindle fire downloadWebCyclophosphamide is an alkylating drug indicated for ... 5.11 Hyponatremia . 6 ADVERSE REACTIONS . 6.1 Common Adverse Reactions . 6.2 Postmarketing Experience •Cardiotoxicity - Myocarditis, myopericarditis, pericardial effusion, arrhythmias and congestive heart free bingo games for fun onlyWebcyclophosphamide should be administered in the morning. 2.1 Dosing for Malignant Diseases Adults and Pediatric Patients . Intravenous When used as the only oncolytic … blockchain cybersecurity risksWebSep 30, 2014 · Although hyponatremia is a rare toxicity it should always be considered during the usage of cyclophosphamide, even if the dosage is low, especially with … free bingo games for cash moneyWebMay 17, 2024 · Hyponatremia occurs when the concentration of sodium in your blood is abnormally low. Sodium is an electrolyte, and it helps regulate the amount of water that's … blockchain cybersecurity trainingWebMar 1, 1977 · Hyponatremia and hypochloremia from SIADH have been described with two cytotoxic agents: vincristine 26,47,82,94,125,129 and cyclophosphamide. 29 Hyponatremia associated with vincristine therapy has been seen in childhood leukemia 47,94,125,129 and in acute granulocytic leukemia in adults. 26,82 Fluid restriction or … blockchain da rfbWebNational Center for Biotechnology Information blockchain dapp